Journal: Frontiers in Public Health

Article Title: Cost-effectiveness analysis of capecitabine maintenance therapy plus best supportive care vs. best supportive care alone as first-line treatment of newly diagnosed metastatic nasopharyngeal carcinoma

doi: 10.3389/fpubh.2022.1086393

Figure Lengend Snippet: Markov model structure. Markov model structure and Markov states are used to evaluating the economic and health outcomes of CBSC and BSC groups as a first-line treatment after induction chemotherapy for patients with mNPC. After initial treatment, patients could experience a response with or without AEs, or experience the disease progression until death. NPC, nasopharyngeal carcinoma; CBSC, Capecitabine maintenance therapy plus best supported care group; BSC, best supported care; AEs, adverse events.

Article Snippet: The Markov model was conducted by using the TreeAge, version 2019 (TreeAge Software, Inc.).

Techniques: Biomarker Discovery

Journal: Microbiology Spectrum

Article Title: Phylogenomics analysis of velvet regulators in the fungal kingdom

doi: 10.1128/spectrum.03717-23

Figure Lengend Snippet: Comparison of the three characteristic motifs of velvet domains among the 21 major clades. The alignment of velvet domains was performed against the profile hidden Markov model of velvet domain PF11754 with 243 residues ( https://www.ebi.ac.uk/interpro/entry/pfam/PF11754/ ) and then subjected to WebLogo ( https://weblogo.threeplusone.com/ ) to generate sequence logos. In the logo, the total stack height represents the information content of residues at that position. The relative height of each residue in the stack is proportional to its frequency at the position, and the residues were sorted so that the most common one was on the top of the stack. The full sequence logos of velvet domains are provided in Fig. S4. The residues are colored according to their chemical properties, of which polar ones G, S, T, Y, and C are in green; neutral ones Q and N are in purple; basic ones K, R, and H are in blue; acidic ones D and E are in red; and hydrophobic ones A, V, L, I, P, W, F, and M are in black. The black balls at the bottom indicate the consensus dominant residues in the 21 clades, and the red balls indicate the other conserved residues revealed by the ConSurf analysis.

Article Snippet: First, multiple alignments of protein sequences within each clade were constructed using HMMER 3.1 ( http://hmmer.org/ ) against the profile velvet hidden Markov model ( https://www.ebi.ac.uk/interpro/entry/pfam/PF11754/ ) in InterPro ( ).

Techniques: Comparison, Sequencing, Residue